The French outfit are keeping in mind the memory of their 2004 Uefa Cup victory over the Italian giants, with the club official maintaining that "anything is possible"
Despite acknowledging that Didier Deschamps' men will face a tough test, Dufoix feels that the memory of their 2004 Uefa Cup victory against the Italian side will be beneficial to Ligue 1 club.
"[Marseille chairman] Vincent Labrune wanted Inter, so we're good," he told the club's official website.
"It will be very complicated, and we get to host the first leg. But we have good memories from 2004 against them."
Dufoix went on to state that the loss of several players to the Africa Cup of Nations in January and February will make things harder for the French side, but called upon his players to make the most of their opportunity among Europe's elite.
"It will also be a good party at the Velodrome," he enthused.
"We have four players that go to the African Cup of Nations, so the first game will be a challenge.
"It's great to be among the last 16. From here anything is possible."
The first leg between the two sides will be played at the Stade Velodrome, before the tie is decided at San Siro.