The Sweden international is back for the Italian champions, and will line up alongside Antonio Cassano as the Czech side visit San Siro for the first time
The giant striker takes his place up front alongside Antonio Cassano just ahead of trequartista Urby Emanuelson in coach Massimiliano Allegri's side. Meanwhile, Antonio Nocerino is preferred to Alberto Aquilani in midfield.
Viktoria coach Pavel Vrba has a full squad to choose from, and will go with a 4-2-3-1 formation to tackle his side's illustrious hosts.
AC Milan (4-3-1-2): Abbiati; Abate, Nesta, Thiago Silva, Antonini; Nocerino, Van Bommel, Seedorf; Emanuelson; Ibrahimovic, Cassano.
Subs: Amelia, Yepes, Bonera, De Sciglio, Taiwo, Aquilani, Ganz.
Viktoria Plzen (4-2-3-1): M. Cech; Rajtoral, Cisovsky, Bystron, Limbersky; Jiracek, Horvath; Pilar, Kolar, Petrzela; Bakos.
Subs: Pavlik, Reznik, Sevinsky, Fillo, Darida, Duris, Trapp.