The Gunners midfielder has warned his Premier League rivals that they need to get in the faces of the Spanish side if they are to have any chance of avenging their 2009 defeat
Arsenal were knocked out in the second round of the Champions League after a controversial defeat against Barcelona which saw Robin van Persie sent off for two bookable offences.
The Gunners had come from behind to take a 2-1 lead to Camp Nou and were ahead on aggregate until Van Persie’s dismissal triggered a Barcelona comeback.
Wilshere was one of the few Arsenal players to come out with credit after a defeat which saw them register no shots on goal during the entire match, and he believes United will have to take the game to the Spaniards if they are to stand a chance, with Sir Alex Ferguson's midfield runners pointed to as being key.
He told reporters: "Three passes - bang, bang, bang - and they are through. You have to get in their faces. I have said it before: you really have to hold your shape.
"United will be good because they have the players like Fletcher who will get after Barca. You have to stop players like Xavi, Messi and Iniesta or they will kill you.
"United have a better chance than we have. They have players like Fletcher, Park, Valencia. They are all 'runners' and they can stop players. I would play Fletcher, just doing what he normally does - running everywhere - and then Carrick and Giggs.
"We played with just Robin van Persie and I would play with just Rooney, with Valencia and Park helping when they get the chance to get forward. For most of it they will be defending because that is what Barcelona do to you."
But Wilshere also revealed his respect for Barcelona's playing style and has tipped them to win on Saturday despite their weaknesses.
"If you can get in their faces they seem to ease off in the second half," he continued.
"We did that in the second half [of the first leg]. I don't think they get tired but you really have to go for them. We beat them at home.
"Obviously the away leg was a different game. After we went down to 10 men we had no chance.
"I think it will be Barcelona because of the way they play. It's the way Arsenal play and the football I like. So if anyone deserves to win, it's Barcelona."