The Gunners' boss says he is expecting Manchester United to change their style to try and beat Barcelona though Wenger believes Pep Guardiola’s team may have played one game too many.
“On what I have seen in the last three weeks, there will never be a better moment to win it against them,” Wenger said in an article in The Telegraph.
“Barcelona look quite exhausted and Man United look quite sharp. For me, it takes three weeks to recover physically. I’m not sure Barcelona will have enough time. They looked on their knees so I would give Man United a good chance.”
This season's Champions League showpiece is being hosted at Wembley and Wenger has highlighted Sir Alex Ferguson’s team’s familiarity with the venue as a factor in their favour.
“It will be an advantage.
“You know that Barcelona will have the ball for 70 per cent of the time and Man United will have to be very efficient in the 30 per cent of the time they have the ball.
“I have an instinctive feeling that Man United will change completely their style against them this time and go for a rougher midfield, a more direct display than they did in Rome [against the same opponents in the 2009 final].
“It can mean playing [Javier] Hernandez, but use him as a runner to go very direct. You know how Barcelona will play. You don’t know yet how Man United will play.”