Manchester United's defensive injury crisis appears to be getting worse by the game as both John O'Shea and Rafael had to be replaced due to injury during the club's Champions League second round second leg match against Marseille.
O'Shea started on the right of a defence that also included Wes Brown, Chris Smalling and captain for the evening Patrice Evra but had to be replaced before half-time as he injured his hamstring whilst United were on the attack.
His replacement, Rafael, was also taken off half-way through the second half for twin-brother Fabio as the right-back also pulled up with a suspected pulled hamstring and had to be stretchered off.
These latest casualties join Nemanja Vidic in the treatment room as the Serbian was declared injured on Tuesday after a day of speculation as to his condition.
The centre-back picked up a calf injury during the 2-0 FA Cup win over Arsenal on the weekend while Jonny Evans and Rio Ferdinand are also currently sidelined meaning boss Sir Alex Ferguson could have something of a defensive problem against Bolton on Saturday.
Sir Alex Ferguson later revealed in his post-match press conference that Rafael and O'Shea could be out for around three to four weeks, with a reporter even asking if Gary Neville could come out of retirement.