The striker was forced off through injury after scoring the opener in Tottenham's 2-1 New Year's Day win at Manchester United - but Sherwood confirmed Adebayor is ready to face the Gunners in the FA Cup.
"I spoke to Ade after United and he said he cramped up in all areas, but thankfully it has settled down and he's ready to perform," Sherwood told reporters.
|16/1||Emmanuel Adebayor is 16/1 with Paddy Power to score two or more v Arsenal|
"It's the biggest game for any Tottenham person, and the manager particularly," Sherwood continued. "We would love to play a lower league team, but it's Arsenal at the Emirates and we can't wait.
"It's a huge competition. It would be fantastic to take Tottenham to the final. It would be the pinnacle of my short managerial career if we went to the Emirates and won and stayed in the hat.
"We'll try to get our offensive players on the ball as much as we can and we feel we can cause them some problems."
Sherwood refused to be drawn on reports linking Tottenham with a move for Manchester City defender Joleon Lescott.
"I'm not looking for any players at moment, I'm just looking to clear that treatment room and assess it once we've got players back," he explained.
"[Lescott] is a good player isn't he? There are a lot of good players at a lot of different clubs and at the moment he's at Manchester City so I can't comment on that."