The two Premier League sides will face each other on Saturday for the right to play in an FA Cup semi-final at Wembley, but the Toffees midfielder expects a tough clash
The Latics are enduring another relegation-battling season as they sit in 17th place, one point above the drop zone, but Osman remembers the two clubs' previous clashes this season being among the toughest for Everton.
February saw Everton have their own slide in form, winning one match from a possible four leaving Osman hopeful of a resurgent March.
Speaking to the club's official website, Osman said: "The two games we have had against Wigan have been right up there with the toughest we have had this season. We have taken four points from the games but they haven't come easily and we know what to expect come Saturday.
"We have had a bit of a sticky patch for the last month. You find it hard to go through a whole season without having one of those. Hopefully now we have got a few players back, Kevin Mirallas is in form, so hopefully we can get back up and running.
"[But] it wasn't doom and gloom. We are still sixth in the league and in the quarter finals of the FA Cup, so it shows the high standards that a defeat or two - one of which was to Manchester United - is counted as a sticky patch.
"There has been a confidence about us pretty much all season. We came out of the blocks quickly and have been playing good football and believing in ourselves."