Demba Ba is Rafa Benitez's preferred man up front today with the Spanish striker left out, while the club captain is back in the starting XI after recovering from his knee injury
Victor Moses has also been handed a starting role, while Fernando Torres has been relegated to the bench with Demba Ba playing up front for the Champions League holders.
David Luiz starts in midfield with Frank Lampard, while Ashley Cole has also been restored to the team as the Stamford Bridge side look to make amends for the shock 2-2 draw at Griffin Park on 27 January.
Harry Forrester scored the second goal against Chelsea in the first match but has to make do with a place on the bench, with Brentford boss Uwe Rosler making two changes to the side that earned the original draw.
Chelsea: Cech; Ivanovic, Cahill, Terry, Cole; D Luiz, Lampard; Oscar, Mata, Moses; Ba.
Subs: Turnbull, Azpilicueta, Bertrand, Ramires, Benayoun, Hazard, Torres.
Brentford: Moore; Logan, Dean, Craig, Bidwell; Forshaw, Diagouraga, Douglas, Adeyemi, Donaldson; Trotta.
Subs: Lee, Barron, Saunders, Hodson, Reeves, Hayes, Forrester.