The West Brom manager expects his players to put right the wrongs of their last-gasp 3-2 defeat to Reading, by beating Harry Redknapp's men in the FA Cup third round replay
West Brom also face a massive derby game at home to Aston Villa on Saturday, when the will be looking to regain their early-season momentum in the Premier League.
The Baggies have slipped to three straight defeats in the league following a great start to the campaign, and Clarke wants the QPR game to be the lynchpin for the rest of their season.
"No, it won’t be hard for the players to play again on Tuesday, they are professional. It’s my job, they’re professional, and we’ve got a big game on Tuesday night. We want to progress in the FA Cup and stay in it as long as possible," he told reporters.
"We want to have a good cup run," he continued. "We owe that to the supporters and we have a massive derby game next weekend.
"Hopefully we can put right the wrongs of the last nine minutes today."
Clarke was also quick to play down rumours of any outgoing transfers in the January window, stating that nobody is leaving the Hawthorns, especially Peter Odemwingie.
"Peter’s not for sale," he said. "I said in the previous press conference none of our players are for sale, with the exception of Graham Dorrans, who we’ve spoken about many times."