Balotelli to lead the line for City despite his form, as Dzeko and Hernandez are moved to the bench whilst there is no place in the squad for Giggs despite his midweek heroics
The suspended Wayne Rooney completes his two-match ban for swearing and is replaced by top scorer Dimitar Berbatov, who plays as a lone striker.
Javier Hernandez, who has been praised by his manager this week, drops to the bench as United to resort to a 4-5-1 formation, with Ryan Giggs completely missing from the 18-man squad. He is replaced by Paul Scholes.
Manchester City boss Roberto Mancini has matched United's formation, with Mario Balotelli replacing Edin Dzeko up front in the absence of Carlos Tevez, who is replaced by David Silva.
Pablo Zabaleta replaces Dedryck Boyata at right-back and Nigel de Jong comes in at the heart of midfield instead of James Milner who was replaced during Monday night's 3-0 defeat against Liverpool.
Man City: Hart; Zabaleta, Kompany, Lescott, Kolarov; De Jong, Barry; Silva, Yaya Toure, Adam Johnson; Balotelli.
Subs: Taylor, Boyata, Vieira, Milner, Wright-Phillips, Dzeko, Jo
Man Utd: Van der Sar; O'Shea, Ferdinand, Vidic, Evra; Valencia, Park, Scholes, Carrick, Nani; Berbatov.
Subs: Owen, Anderson, Smalling, Hernandez, Fabio, Gibson, Kuszczak