Stand-in captain Tomas Rosicky is the only player to retains his place in the starting line-up - with the likes of Nicklas Bendtner, Marouane Chamakh and Denilson given their chance to show why the should feature heavily in Arsenal's busy run-in.
The biggest surprise in Wenger's starting XI is the inclusion of young midfielder Conor Henderson - who makes his first-team debut.
The 19-year-old is a technically gifted midfielder, renowned for his ball-playing abilities but is a surprise inclusion in the Arsenal team after making just seven reserve-team appearances last season.
Reserve captain and cultured centre-half Ignasi Miquel also starts the game, after making his first team debut in the 1-1 draw between Arsenal and Leyton Orient on February 20.
Despite earning Orient a lucrative replay at the Emirates tonight with his 89th-minute equaliser, Jonathan Tehoue is not given a place in the starting XI and will take his place on the bench once again.
Arsene Wenger admitted he had not heard of the French striker before the last meeting between the two teams but you can be assured that his defence will be aware of the physical presence Tehoue offers if he appears as a substitute again tonight.
Arsenal: Almunia; Eboue, Squillaci, Miquel, Gibbs; Diaby, Denilson, Rosicky; Henderson, Bendtner, Chamakh. Subs: Sagna, Nasri, Wilshere, Djourou, Clichy, Arshavin, Szczesny.
Leyton Orient: Jones; Crowe, Chorley, Forbes, Whing; Cox, Dawson, Carroll, Daniels; McGleish, Revell. Subs: Omozusi, Chambers, Butcher, Spring, Tehoue, Cestor, M'poku.