The Latics will be looking to end a run of four straight defeats when they face Bolton on Sunday, while table-toppers Burnley travel to third-placed Leicester on Saturday lunchtime
Former Brentford manager Rosler was appointed as Wigan's new boss – replacing Owen Coyle – last week and has promised to bring back an attractive style of football to the DW Stadium.
Wigan are currently languishing in 14th in the Championship after four consecutive league defeats but Rosler is excited about the challenge as he bids to take last year's FA Cup winners into the Premier League at the first attempt.
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"The players will be up for it and it's a great opportunity for us. Bolton are in a similar region to where we are in the table.
"It is a very important game. Both teams have to win but I am sure we will put ourselves in a good position."
On Saturday, Burnley go to third-placed Leicester City on the back of a much-needed victory.
Sean Dyche's team ended a six-match winless streak in all competitions with an unconvincing 1-0 home triumph over bottom side Barnsley last week.
Burnley's top scorer, Danny Ings, is doubtful with an ankle injury that has slowed his stunning start to the season.
Leicester – who have won nine of their 11 home matches in all competitions – will enter the match off the back of successive away defeats to Sheffield Wednesday and Brighton and Hove Albion.
At the other end of the table, Barnsley will hope to climb off the foot of the table when they host Yeovil Town.
Barnsley have the league's worst defence – they have shipped 37 goals in 19 matches – and with just three wins on the board, must improve.
Yeovil have been resurgent in recent weeks, though, backing up wins over Watford and Blackpool with a 2-2 draw against Charlton Athletic on Saturday, lifting them to 22nd.
QPR – who sit second in the table – face a tricky trip to Blackpool but may be catching them at the right time.
Paul Ince's men have had five players sent off in their last two fixtures and Ricardo Fuller, Angel Martinez and Neal Bishop are suspended for the match.
Meanwhile, Derby County are flying high after five successive wins and the Championship's top scorers with 40 goals go to Charlton Athletic, while Leeds United will be hoping Ross McCormack continues his form in a Yorkshire derby against Doncaster Rovers.
McCormack, who is the league's top scorer with 15 goals, has netted 10 in his last six matches.
Nottingham Forest and Reading, who are also in the play-off picture, face Ipswich Town and Huddersfield Town respectively.
Managerless Sheffield Wednesday visit Watford, while other fixtures across the weekend see Blackburn Rovers battle Millwall, Bournemouth tackle Birmingham City and Middlesbrough meet Brighton and Hove Albion.