The Welsh side have announced the former director has left his role with immediate effect as he looks to embark on new business ventures having been at the club for four years
The Malaysian was appointed in his role a year after becoming director in May 2009, helping the club find foreign investment by introducing current owner Vincent Tan.
Tien Ghee, who was given the nickname TG by supporters of the club, is looking to further his business interests and can therefore no longer commit to spending time with the Welsh club.
"We wish to confirm that Dato Chan Tien Ghee (TG) has resigned as chairman and director of Cardiff
City Football Club with immediate effect," read a statement from the club's official website.
"TG is embarking on new career and business pursuits that requires his full attention.
"Given constraints of time and distance, TG believes he is unable to meet the demands of his position as Chairman and board member of Cardiff City Football Club."
Cardiff had struggled with debt problems under former chairman Peter Ridsdale, whose search for investment from the Middle East led to the appointment of Tien Ghee as director.
Tien Ghee took over in the role as chairman the following year and, in persuading business partner Vincent Tan to become another of the club's Malaysian investors, he helped the club begin a new era without financial difficulties.
The statement continued: "We are greatly indebted to TG who since joining in 2010 has been instrumental in the progress of the club to where it is today, and we wish to record our deep appreciation for his invaluable contributions and efforts.
"We wish TG all the very best in his new undertakings."