The clubs renewed rivalries at youth level, with first-team players for both clubs making injury comebacks
Winger Valencia had been out of action since October's 0-0 derby draw with Manchester City, while Skrtel was returning to the pitch for the first time since the Reds' 3-0 defeat at Watford in December.
Skrtel got through an hour at Prenton Park while Valencia was withdrawn at the interval, replaced by recent senior debutant Timothy Fosu-Mensah.
First-teamers were on display for either side as Adnan Januzaj, Steven Caulker and Jordon Ibe all featured.
The game finished 1-1 after United youth captain James Weir - another player to make his first-team bow in recent weeks - cancelled out Jerome Sinclair's opener.