The Hammers have confirmed that the on-loan Arsenal defender has suffered substantial damage to his left knee and will see a specialist on Wednesday
The full-back, who is spending the 2015-16 campaign with the Gunners' London rivals, was hurt in the challenge with Sergio Aguero which led to Manchester City's penalty in the 2-2 Premier League draw between the teams at Upton Park on Saturday.
Initial reports suggested Jenkinson could be out for the rest of the season but neither West Ham nor Arsenal have placed a time frame on the 23-year-old's expected absence as he awaits further assessment this week.
"West Ham United can confirm that Carl Jenkinson injured his left knee during the early stages of Saturday's Premier League fixture with Manchester City," a West Ham statement released on Tuesday confirmed.
READ MORE | Wenger: Seeing Sanchez was like getting a slap in the face
"Unfortunately, it appears that Carl has suffered a significant injury and he will be assessed by a specialist in central London on Wednesday.
"A further update will be provided when the full extent of the injury has been confirmed."
Arsenal added: "The thoughts and best wishes from everyone at Arsenal are with Carl, and we all wish him a successful recovery."
Jenkinson has made 23 appearances for West Ham in all competitions so far this season.