Brendan Rodgers has handed Mario Balotelli a debut and a place in his starting XI as Liverpool take on Tottenham at White Hart Lane.
The Italian, who moved to Merseyside in a £16 million deal from AC Milan last week, partners Daniel Sturridge in attack, while Philippe Coutinho drops to the bench.
New signing Alberto Moreno, who made his debut in the 3-1 defeat to Manchester City on August 25, continues at left-back.
Mauricio Pochettino, meanwhile, names an unchanged side from the team that hammered QPR 4-0 last week, while new signing Federico Fazio is not picked in the matchday squad.
Goalkeeper Hugo Lloris and centre-back Younes Kaboul are the only two players to have started the 3-0 Europa League victory over Limassol on Thursday who line up as part of Pochettino's starting XI.
Roberto Soldado, who missed the midweek win through injury, does not make the bench for Spurs, and Paulinho also misses out.
TOTTENHAM: Lloris; Dier, Kaboul, Vertonghen, Rose; Bentaleb, Capoue; Chadli, Eriksen, Lamela; Adebayor.
Subs: Friedel, Chiriches, Davies, Dembele, Holtby, Townsend, Kane.
LIVERPOOL: Mignolet; Manquillo, Lovren, Sakho, Moreno; Henderson, Gerrard, Allen; Sterling, Sturridge, Balotelli.
Subs: Jones, Enrique, Toure, Lambert, Coutinho, Can, Markovic.