The Belgium international starts for the Blues, while the £32 million signing from Atletico Madrid leads the line against the newly-promoted outfit at Turf Moor
The Belgian replaces Petr Cech in goal for the Blues, with the Czech Republic international relegated to the bench. The match will mark Courtois' first competitive start for the club, following his return from three consecutive loan spells at Atletico Madrid.
Costa begins up front, ahead of Fernando Torres and Didier Drogba, while fellow new signing Filipe Luis starts the game on the bench.
Burnley, meanwhile, field ex-Manchester United stopper Tom Heaton in goal, with Danny Ings and Lukas Jutkiewicz picked to lead the line as the Clarets go in search of a major upset.
Burnley: Heaton; Trippier, Shackell, Duff, Mee; Arfield, Jones, Marney, Taylor; Ings, Jutkiewicz.
Chelsea: Courtois; Ivanovic, Cahill, Terry, Azpilicueta; Fabregas, Matic; Schurrle, Oscar, Hazard; Diego Costa.
Subs: Cech, Zouma, Filipe Luis, Mikel, Willian, Torres, Drogba