Louis van Gaal has been forced to pick two untried youngsters as he prepares to take charge of his first competitive match at Old Trafford as the Red Devils manager
The Dutchman has, as expected, implemented his preferred 3-4-1-2 formation, which will see Herrera's Spanish compatriot Juan Mata operate behind a front two of Javier Hernandez and new United captain Wayne Rooney.
Robin van Persie misses out having been handed an extended break by Van Gaal after leading the Netherlands to third place at the World Cup, while United's other major summer signing Luke Shaw is out with a hamstring injury.
Lingard, who spent the majority of last season on loan at Birmingham, is expected to play in a wing-back role, where he operated on Tuesday against Valencia, while Blackett comes into the centre of defence as Jonny Evans is absent.
For Swansea, Lukasz Fabianski makes his debut in goal following his summer move from Arsenal while Wilfried Bony, a transfer window target for Liverpool and Tottenham, starts in attack looking to repeat last season's heroics when he scored the goal that knocked United out of the FA Cup and help the Welsh side record their first ever win at Old Trafford.
Manchester United starting XI: De Gea; Jones, Smalling, Blackett; Lingard, Fletcher, Herrera, Young; Mata; Rooney (c), Hernandez.
Subs: Amos, James, M Keane, Fellaini, Kagawa, Nani, Januzaj.