Van Gaal made the ideal start to his tenure in charge of United, leading them to a 7-0 friendly win over LA Galaxy, before the club recorded a 3-2 triumph over Roma to kick-start their International Champions Cup campaign.
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"That's why I chose this system, I can play them all. But Hernandez can also play in the striker's position, so can Welbeck," the Dutch tactician told Sky Sports.
"Rooney can play at number 10 and number nine and he tells me he can also play at number 11 and number seven, but I prefer him at number nine or number 10.
"When you look at the quality of your players you see Rooney, Van Persie, Hernandez, Mata, Welbeck, [Marouane] Fellaini, [Ander] Herrera – a lot of players can play this system.
"So with this system, two strikers can play, the number 10 can play, two midfielders can play, so the specialists become the wing-backs."
Van Gaal also revealed his reasons for accepting the United job, after being identified as the ideal successor to sacked David Moyes.
"It was not an instant 'yes' because I had other offers also. So I had to think about it," he said.
"But I chose 'yes' because of the big challenge. I have been at Ajax – the biggest club in the Netherlands – I went to Barcelona – the biggest club in Spain – and then I go to Bayern Munich, also the number one in Germany.
"So when Manchester United came I thought I had to say 'yes'."