The 23-year-old arrived at St James' Park from Inter in 2011, and has since made 82 Premier League appearances in three seasons.
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Santon still has two years left on his current deal at Newcastle, but has been linked with a move back to his homeland.
However, the Italy international told Sky Sport Italia that such a switch was unlikely during this off-season.
"There has been interest from Milan and Roma for me, but I have two more years on my contract with Newcastle and I don't know if they want to sell me," he said.
"I'm fine at Newcastle, I immediately felt at home there and I like the Premier League.
"I think I won't return to Italy this summer."