The Argentine has been handed a long-term deal by Daniel Levy to succeed Tim Sherwood after an impressive 18 months in charge of Southampton
Tottenham have confirmed that Mauricio Pochettino has been named the club's new manager.
Goal revealed on Monday morning that Spurs had reached an agreement with the former Espanyol boss, worth £3 million per season.
Southampton announced on Tuesday afternoon that the Argentine had left the Saints, with Spurs releasing official confirmation shortly afterwards.
|THE PERFECT FIT
|COMMENT: How Pochettino appointment can revitalise Tottenham|
Pochettino, who will bring several of his coaching staff with him to White Hart Lane, said: "This is a club with tremendous history and prestige and I am honoured to have been given this opportunity to be its head coach.
"There is an abundance of top-class talent at the club and I am looking forward to starting work with the squad.
"Tottenham Hotspur has a huge following across the world and I have great admiration for the passion the fans show for this team. We are determined to give the supporters the kind of attacking football and success that we are all looking to achieve."
Chairman Daniel Levy added: "In Mauricio I believe we have a head coach who, with his high energy, attacking football, will embrace the style of play we associate with our club. He has a proven ability to develop each player as an individual, whilst building great team spirit and a winning mentality.
"We have a talented squad that Mauricio is excited to be coaching next season."
The Club is delighted to announce the appointment of Mauricio Pochettino as our new Head Coach on a five-year contract.— Tottenham Hotspur (@SpursOfficial) May 27, 2014
Jesus Perez will join as Pochettino's assistant, Miguel D'Agostino has been named first team coach and Toni Jimenez will work as goalkeeper coach.
Pochettino moved to English football in January 2013, replacing Nigel Adkins at Southampton. His appointment was originally met with scepticism, but he got the Saints to Premier League safety and last season masterminded an eighth-place finish.
Tottenham's statement welcoming Pochettino's arrival hailed his ability to nurture young players, citing Saints stars Luke Shaw, Adam Lallana, James Ward-Prowse and Calum Chambers in particular.