The Dutchman was officially appointed as the club's new manager on Monday but how will he get on in his debut campaign at Old Trafford? Is the title a realistic possibility?
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The Dutchman, who has already spoken of his big ambitions ahead of taking permanent control of the club after his World Cup commitments with Netherlands, has an impressive CV and has won countless titles with the likes of Barcelona and Bayern Munich.
But he inherits a United squad seemingly in need of a complete revamp after a disastrous campaign that saw the club finish the season with their lowest points total in the Premier League era, breaking numerous other unwanted records along the way under former boss David Moyes.
As revealed by Goal, Van Gaal has a number of talented transfer targets in mind with the likes of Kevin Strootman, Mats Hummels and Toni Kroos all on the wanted list, while many of the Red Devils' under-performing stars are set to be given the boot.
But will that be enough to get United back to the Premier League's summit? Is a place back in the Champions League as far as their ambitions should stretch next season? Are they even capable of achieving a top-four finish?
What do you think? How will Van Gaal get on in his first season at Old Trafford? Could United fans be dreaming of a title-winning campaign, so often delivered under legendary boss Sir Alex Ferguson, or do you expect it to be another challenging season for the Red Devils?
Have your say by voting in our poll and make sure you leave your comments below!