The England striker sat out Saturday's 1-0 defeat against Sunderland as he has been hampered by a bug as well as a hamstring problem.
Interim United manager Ryan Giggs revealed on the eve of Tuesday's Premier League clash with Steve Bruce's side that his leading scorer may have played his last game of the campaign at Old Trafford.
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|2/1||Juan Mata is 2/1 with William Hill to score in a Manchester United win over Hull City|
"He's not quite recovered. We'll continue to monitor him."
Giggs, who is considering selecting himself to play against Hull, also revealed that Jonny Evans is not expected to feature in the final two games of the season due to a calf injury.
There is more positive news of fellow defender Rafael, who is set to be back in contention to face the FA Cup finalists and Southampton on the final day.
"Rafa has trained in the last few days and looks good," Giggs enthused. "He could be involved in the remaining two games."
United could still climb into sixth place - and Europa League qualification - if they win both games and Tottenham lose to Aston Villa on Sunday.