Chelsea host the Gunners for the Frenchman's landmark game in charge and insisted he admires the Gunners boss but also pointed out "a lot" of difficult moments along the way
Saturday's clash at Stamford Bridge sees the Premier League's longest-serving manager reach the landmark in the top-of-the-table clash as the two title contenders face off.
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"The tribute is to say I believe that any one of us, we would love to have the same privilege with our clubs," he told reporters.
"I admire him and I admire Arsenal. I's not possible to have 1000 matches unless the club is also a fantastic club who support their managers especially through the bad moments and especially when the bad moments were quite a lot.
"So I admire the manager and I admire the club."
Mourinho returned to Chelsea for a second spell last summer, with Saturday's clash marking his 231st in charge of the Blues, and he says reaching just half of Wenger's landmark would be impressive.
He added: "I would like to. But it's very, very difficult. It was always difficult but in modern football it's even more difficult. But if I can relate my first three-and-a-half years with Chelsea, and this one, I have a few.
"If I can reach I would say 500, it would be fantastic."