The duo were prolific earlier in the season, and have scored 49 goals between them already in the current campaign, though a hamstring injury suffered by Aguero means they have not appeared together since a routine victory over West Ham in the Capital One Cup in January.
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|9/2||Alvaro Negredo is 9/2 with bet365 to open the scoring against Wigan|
"In that moment (earlier in the season), it was very productive for the team – and I hope in the future it can be again," said the Chilean manager.
"But in other moments when Sergio was injured, Negredo played very well at that time.
"It's important to have important strikers. Strikers also live from the goals they score. Alvaro will return to his normal performance. He will continue scoring goals."
City face Wigan at the Etihad Stadium on Sunday in the quarter-finals of the FA Cup - a repeat of last year's final, in which Wigan won 1-0.