The Argentina international has been given permission to return to South America following the news.
Newcastle revealed Coloccini's absence on Friday, posting a short statement on their official website.
It read: "Newcastle United captain Fabricio Coloccini will not be involved in Saturday's Barclays Premier League fixture at Hull following a family bereavement.
"The centre-back has been allowed to return home to Argentina to spend time with family rather than make the trip to the KC Stadium."
Coloccini only returned from a knee injury last weekend, making his 17th Premier League appearance of the season in the Magpies' dramatic late 1-0 win over Aston Villa.