The Germany international was left out of the 4-1 win over Sunderland following a below-par performance against Bayern Munich in the Champions League that saw the 25-year-old miss from the penalty spot.
|22/1||Mesut Ozil is 22/1 to score two or more goals for Arsenal away at Stoke this weekend|
The Gunners boss told reporters: "Vermaelen and Ozil are back in the squad, we have doubts over [Nacho] Monreal and [Kieran] Gibbs.
"Ozil had a difficult game [against Bayern] and sometimes it's good to refresh when you are under pressure."
Wenger also commented on Joel Campbell following the on-loan Olympiakos striker's impressive performance that saw him score his side's second goal in the 2-0 win over Manchester United on Tuesday.
Asked if he would be a part of the first-team set-up at the Emirates Stadium next season, the Frenchman said: "I will decide that later. Why not? We bought him to bring him here.
"He was good, convincing going forward [against Man United]. He looks like he has adapted a bit better to the physical side of the European game.
"We always knew that he had the talent to create something special. He did rely a bit too much on that.“But he's now been out with three different clubs; he was with Lorient, Real Betis and now Olympiacos. He has learned the toughness of the European leagues."