The south-coast club confirmed the nature of both players' injuries, which were sustained in Saturday's 2-2 draw at Sunderland, on Wednesday.
|7/2||Southampton are 7/2 with Paddy Power to finish in the bottom half|
A statement on Southampton's official website read: "Saints can confirm that Dejan Lovren and Gaston Ramirez both suffered ankle ligament injuries during Saturday's 2-2 draw with Sunderland at the Stadium of Light.
"The pair both flew back to Southampton with the rest of the squad on Saturday evening, and have since been recuperating at Staplewood.
"The players' injuries are still being assessed by the medical team, so we are reluctant to place a timescale on when the duo will be able to return to action.
"We will keep supporters updated on the pair's recovery and, as soon as we are in a position to comment on their anticipated recuperation time, we will do so."