The 21-year-old Swede's career has stalled due to injury and he has emerged as a target for Stoke.
Hughes is eager to bolster his squad this month in order to avoid being dragged into a relegation battle, as his side are only four points above the Premier League relegation zone.
And the former Fulham boss confirmed after Sunday's 5-3 defeat against Liverpool that Guidetti could arrive at the Britannia Stadium.
When asked about the likelihood of Guidetti signing, he told reporters: "Possibly. We've spoke about the boy.
"We hope to get players in who can help us. If we're able to conclude that then it be something that would help all parties.
"We're looking to add players if we can. There's certain parts of our game we know we need a different option.
"Sometimes we haven't got that option to go in behind and we lack a little bit of pace so we'd like to try and address that.
"We've been looking since the summer to do that, but obviously we haven't managed it but that's an obvious part of our play and the team that needs addressing."
Guidetti enjoyed a fruitful loan spell at Feyenoord in the 2011-12 campaign, scoring 20 goals in 23 appearances for the Eredivisie outfit.
Hughes also revealed that Stoke are close to signing on-loan midfielder Stephen Ireland on a permanent deal.