The Potters boss, who will have to adapt his side for their match against Everton, feels that his side have had refereeing decisions go against them so far this season
The Potters were beaten 5-1 at St James's Park, having two men sent off in the process, before Tottenham scored three goals without reply on Sunday.
With minor injuries and illnessnes to the likes of Asmir Begovic, Andy Wilkinson and Stephen Ireland, Hughes has some selection difficulties for Wednesday's visit of fourth-placed Everton, though Glenn Whelan and Marc Wilson return from their suspensions and the manager is determined to remain upbeat.
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"We are at home so we will go out there and put in a performance to win the game.
"We have had a few decisions go against us recently, so we are hoping our luck will change. We also have a very good home record so we will be looking to continue that on Wednesday.
"Andy Wilkinson is unfortunately injured and is a doubt for the Everton match but everyone else, apart from Begovic [Robert] Huth is fit.
"Wilko picked up a heel injury in the game at White Hart Lane and is struggling [but] we have players who have served their suspensions, so we have more options to choose from."
Stoke sit 12th in the Premier League, five points above the relegation zone, but have lost only one league game at home this season.