Michael Laudrup's men qualified for the round of 32 in the Europa League on Thursday, despite losing 1-0 to St Gallen in Switzerland.
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"[The break] is a big chance to press on in the Premier League," De Guzman told the press.
"We have a lot of games coming up over the next two months and it will be great for us to be able to really focus in on the league and try to move up the table.
"It will be difficult but this was the time when we put a good run together last season so hopefully we can do the same again."
De Guzman and his team-mates visit Norwich City on Sunday hoping to maintain their position in the top half of the table but he knows that beating Canaries, who have won three of their last five games, will not be easy.
"It will be an open game against them but we have to go there and show our quality and be ready to fight for the win," he remarked. "We have to step up."