The Potters suffered their first Premier League loss since October 26 on Saturday as the Toffees romped to a 4-0 victory at Goodison Park but they have an opportunity to quickly recover, with Wednesday's game against Cardiff City the first of two at the Britannia Stadium in four days.
Having overseen just one defeat on home soil - against Norwich City - this season, Hughes is hopeful that his side can build some momentum ahead of Chelsea's visit on Saturday.
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"Everton were better than us and deserved to win but the scoreline didn't make great reading. We'll get a response.
"We had four games unbeaten [in all competitions prior to the Everton game] and the onus on us now is to go on another run, continue to be strong at home.
"Cardiff are a hard-working side; we will have to match that, given we're the home side. If we do that, we can take it away from them."
Forward Jonathan Walters, who has made 103 consecutive league appearances for Stoke, has emerged as a doubt for the Cardiff clash but there is an outside chance that Marko Arnautovic, who had initially been ruled out with a hamstring problem, could feature.
"Jonathan Walters is the only player from the weekend struggling," Hughes confirmed. "He's got a little problem with his thigh and so we have to check on that closer to the game but, apart from that I think we should be OK."
"[Arnautovic] is back up and running again now but it is one where we will have to have another look at him. Realistically it will probably be a bit too soon for him and Chelsea is the more viable option for him to return but we will assess him and make a decision."