|8/1||Spurs are 8/1 with Bet365 to bounce back and win both halves against Manchester United|
Sandro scored an own goal before the prolific Sergio Aguero helped himself to a brace, with Alvaro Negredo then getting in on the act and Navas completing the rout with his second goal right at the death.
This was Spurs' fourth Premier League defeat this season and Villas-Boas was baffled by the loss.
"[It was a] difficult start. Conceding after 15 seconds puts your plans in doubt, it's difficult to take," he told reporters. "I think we had a very good reaction to the [opening] goal, that’s probably the only positive of the game we have.
"Everything went bad for us, from being one of the best defences in the country to suffering six goals, there's not a lot I can say.
"City were excellent, we were extremely poor today and we paid a big price. From the moment we suffered the fourth goal we mentally weren’t playing the game."
Tottenham now find themselves down in ninth place and face Manchester United in their next league fixture.