Though Andre Villas-Boas had previously indicated that he would field the French goalkeeper on Sunday, he was omitted from the matchday squad under medical advisement
The France captain collided heavily with Romelu Lukaku in November 3's 0-0 draw at Goodison Park and was knocked unconscious after the Belgian's knee clattered into to the side of the head.
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However, after being rested against Sheriff in the Europa League in midweek, Lloris again found himself out of Andre Villas-Boas's matchday squad to face Newcastle on Sunday, with Friedel again between the sticks and Heurelho Gomes on the bench.
Tottenham's head of medical services, Wayne Diesel, believes that the rest will be crucial for their No.1, explaining: "We've continued to monitor Hugo all week and, after discussions, Andre and the medical department have agreed to afford the player a couple more days rest.
"Hugo is naturally disappointed as he was keen to return to action. However, we feel this decision is in the player's best interest."