The Canaries manager saw his men drop into the relegation zone after their humbling at the Etihad Stadium, their sixth Premier League defeat of the season, and has come under increasing pressure for his side's poor start despite a summer spending spree of over £20 million.
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Hughton told reporters: "It's our responsibility to get a reaction from the Manchester City game this weekend.
"Any negatives are in the past. We have faith in the ability that we have. The value of winning a couple of games is huge.
"We have to concentrate on ourselves. It's not about West Ham. It's a home game for us."
Hughton also confirmed that Netherlands striker Ricky van Wolfswinkel - who cost Norwich £8.5m but has scored just one goal this season - will miss the match with a foot injury.
Nathan Redmond will be given until the last minute to prove his fitness following a hip problem, while Scottish winger Robert Snodgrass is fine to play after recovering from concussion.