The Canaries have had a shaky start to the new campaign, winning just two of their opening eight fixtures, and now languish in the bottom three.
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But Cardiff have also lost their last two games and sit just one place and one point above their hosts.
History narrowly favours the hosts, with the previous ten meetings between the two teams ending in victory for Norwich on five occasions.
This encounter will be the first time they have faced each other in the top flight, however, and Hughton will hope to welcome striker Ricky van Wolfswinkel back into the side after a foot injury ruled him out last weekend.
The 24-year-old, who joined from Sporting Lisbon in the close-season, has become an integral part of the manager's plans, starting seven of the club's eight fixtures and netting against Everton in the season opener.
Hughton confirmed Van Wolfswinkel will need to undergo a late assessment ahead of the clash, though, while also revealing that fellow-striker Johan Elmander will be available after re-joining training following a thigh complaint.
Cardiff boss Mackay, on the other hand, does not have any new concerns, with long-term absentee Andreas Cornelius still out after suffering an ankle injury in pre-season.