The Spaniard returns from an ankle injury at the expense of the Welshman, while there are maiden Premier League starts for Willian at Chelsea and Adnan Januzaj at Manchester United
|16/1||Arsenal are 16/1 with BetVictor to win the Champions League
Earlier this week, Goal revelead that the Spaniard is set for his Arsenal comeback and manager Arsene Wenger has duly restored Cazorla straight back to his side's starting XI.
Welshman Ramsey makes way for the 28-year-old, as Jack Wilshere, Mathieu Flamini, Mikel Arteta and Mesut Ozil continue in midfield for the Gunners.
Norwich City, meanwhile, hand a start to summer-signing Gary Hooper as Ricky van Wolfswinkel misses out.
Arsenal: Szczesny; Sagna, Koscielny, Mertesacker (C), Gibbs; Wilshere, Arteta, Flamini, Cazorla, Ozil; Giroud
Subs: Fabianski, Vermaelen, Rosicky, Ramsey, Monreal, Bendtner, Jenkinson
Norwich City: Ruddy; Martin, Bassong (C), Turner, Olsson; Tettey, Fer, Howson; Snodgrass, Pilkington; Hooper.
Subs: Bunn, Whittaker, Johnson, Hoolahan, Becchio, Redmond, R Bennett.
Meanwhile, Manchester United have handed Adnan Januzaj his first competitive start at Old Trafford, while Robin van Persie also starts for David Moyes' side.
Januzaj scored twice in United's win over Sunderland in their last Premier League fixture and this morning signed a new five-year deal with the club.
Dutchman Van Persie, who previously had trouble with a toe injury, also starts for the home side alongside Wayne Rooney.
For visitors Southampton, Rickie Lambert drops to the bench as Jay Rodriguez starts alongside Dani Osvaldo.
Manchester United: De Gea; Rafael, Jones, Evans, Evra; Nani, Carrick, Fellaini, Januzaj; Rooney, Van Persie.
Subs: Lindegaard, Giggs, Smalling, Hernandez, Welbeck, Kagawa, Zaha.
Southampton: Boruc; Clyne, Fonte, Lovren, Shaw; Wanyama, Schneiderlin, S. Davis, Lallana (C); Rodriguez, Osvaldo.
Subs: K. Davis, Lambert, Ward-Prowse, Cork, Guly, Chambers, Hooiveld.
Meanwhile, Chelsea have given Willian his first ever Premier League start as Kevin De Bruyne can only make the bench for Jose Mourinho's side.
The Brazilian starts alongside Juan Mata and Eden Hazard, with Oscar also demoted to the bench, while Samuel Eto'o starts ahead of Fernando Torres.
Cardiff City make two changes from their last Premier League outing as Jordon Mutch and Don Cowie come in for Kim Bo and Campbell.
Chelsea: Cech; Ivanovic, D Luiz, Terry (C), Bertrand; Ramires, Lampard; Willian, Mata, Hazard; Eto’o.
Subs: Schwarzer, Azpilicueta, Cahill, Essien, Oscar, De Bruyne, Torres.
Cardiff City: Marshall; Taylor, Caulker (C), Turner, Whittingham; Medel, Gunnarsson, Mutch, Cowie, Theophile-Catherine; Odemwingie.
Subs: Lewis, Hudson, Campbell, Kim, Gestede, Noone, Maynard.