Andre Villas-Boas' men have won three of their four Premier League games on the road this season, beating Stoke, Crystal Palace and Cardiff, but they slipped to a 1-0 loss against rivals Arsenal.
The visitors are a best priced 21/20 (2.05) to win at Villa Park but new Paddy Power customers can make the most of the bookmakers' price of 4/1 (5.0) when opening a new account.
With both Manchester clubs encounters blips in their early season form under new management, Villas-Boas will be hoping that his side can get back into the Champions League despite selling Gareth Bale to Real Madrid in the summer.
Roberto Soldado was one of the headline signings in a busy transfew window for Spurs and the former Valencia man is 5/1 (6.0) favourite to open the scoring at Villa Park on Sunday afternoon with Paddy Power and 7/5 (2.40) to score anytime.
It was Jermain Defoe who led the line against West Ham though, following a couple of impressive performances in Europe, and he is 11/2 (6.50) to break the deadlock.
Paul Lambert will be hoping he can call on the services of a fully fit Christian Benteke, who has five goals in all competitions for the home side. The Belgium international is available at 21/10 (3.10) to score anytime.
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Jim Knight is Betting Editor at Goal.com and has been tipping football games since he was old enough to place a bet. He is a Leicester City fan, writer and member of the We Are Going Up Podcast