The defender has been out of action for a month due to an ankle problem and will not be risked on Saturday, but could be in contention for Thursday's Europa League match
The Wales international has not featured for a month but was named as a substitute for the defeat against Southampton before linking up with the Wales team on international duty.
However, his manager insists the Sunderland match has come too soon for the 29-year-old, although he could be in contention for next week’s Europa League game against Kuban Krasnodar as he attempts to regain match practice in time for the upcoming South Wales derby against Cardiff.
"Ashley was on the bench at Southampton and he could maybe have played for ten or 15 minutes, but he will not take part this weekend," Laudrup told the South Wales Evening Post.
"He went to join up with Wales and the doctors there saw what we had seen - everybody could see that he was not 100 per cent.
"They all said he needed maybe one or two weeks to recover.
"Even if he trains tomorrow and feels okay after a couple of sessions, he still has to get match fitness back.
"If everything goes well, we could maybe look at the game next Thursday or West Ham.
"I know Ashley would like to play a game before Cardiff - but I will not risk him."