Hughes spent just a season at the west London club, leading them to eighth in the Premier League before resigning, citing a lack of ambition.
The Welshman subsequently took over at QPR though was sacked after a winless start to the 2012-13 season, and the 49-year-old admits he may have left Fulham too soon."It will be nice to go back to Fulham. In hindsight maybe I made the wrong decision," Hughes told reporters.
Stoke are 8/1 with William Hill to beat Fulham 1-0
"I questioned the way that the club wanted to move forward, but they have moved forwards so I was wrong.
"I had a great year there. We finished eighth in the Premier League, and I think that only on one other occasion have they finished higher than that.
"It was a successful year there, but I made the decision to leave, and like I say, in hindsight it was the wrong decision.
"I don't think I am going there with a point to prove. I am sure that most Fulham supporters will have looked at the job that I did there, and be very happy with it."
A reported training-ground bust-up between Kenwyne Jones and Stoke captain Ryan Shawcross has dominated headlines at the Britannia Stadium in the week.
Shawcross has already moved to deny that he and the Trinidadian engaged in an altercation and Hughes also strongly refuted the claims.
He added: "What was in the papers this week was pure fabrication. Why whoever wrote the story this week wanted to go down that route, I just don't know. Maybe they had an agenda, I'm not sure."