The Brazilian is confident him and his team-mates are capable of making amends for the 4-2 loss last season, and hailed the impact compatriot Paulinho has had at White Hart Lane
The west London outfit ran out 4-2 winners in the corresponding fixture last season, but Spurs come into the game having won four of their five Premier League games and are yet to concede a goal at home this term.
And Sandro, who opened his account for Tottenham with a 35-yard goal against Chelsea in April, 2011, says the squad are "determined" to beat their cross-city rivals and make amends for 11 months ago.
"Chelsea is a great game and everyone is looking forward to it," the Brazil international told the club’s official website.
"Last season we lost at home and this season we're determined to win. We have to play like we played at Villa. Let’s try and take this big win."
Tuesday's resounding 4-0 win over Aston Villa in the Capital One Cup signalled Sandro's first start alongside compatriot Paulinho in the centre of midfield, and the former is delighted with the £17 million man's impact at the club.
"It was my first time to play with Paulinho and he’s amazing," he continued. "He's on fire at the moment! I’m so glad for him and everyone enjoyed this moment."