Robin van Persie has been ruled out of Sunday's Manchester derby at the Etihad Stadium with a groin injury.
The Manchester United striker has been replaced by Danny Welbeck, and will lead the line against Manchester City with Wayne Rooney.
"It was a groin strain during the week. We thought he'd be okay today but not quite. Up to this morning we gave it every chance he had a real opportunity of making it." said United boss David Moyes.
"It's nothing serious, it might keep him out for a few days, we don't think it's too bad."
Elsewhere, Shinji Kagawa makes an appearance on the substitutes' bench and Marouane Fellaini is handed his first start in United colours.
Manuel Pellegrini makes one change from the team held by Stoke City last weekend, with Alvaro Negredo coming in for Edin Dzeko. Vincent Kompany, Fernandinho, Jesus Navas and Sergio Aguero all start by David Silva misses out after failing to overcome a thigh injury.
Manchester City: Hart, Zabaleta, Kompany, Nastasic, Kolarov, Nasri, Fernandinho, Toure, Navas, Aguero, Negredo
Subs: Pantilimon, Lescott, Richards, Garcia, Milner, Jovetic, Dzeko
Manchester United: De Gea, Smalling, Ferdinand, Rooney, Evra, Vidic, Carrick, Fellaini, Young, Valencia; Rooney, Welbeck
Subs: Amos, Buttner, Evans, Cleverley, Nani, Kagawa, Hernandez