The 52-year-old says his side must play with "no fear" when they face last term's runaway Championship winners, stressing the importance of picking up points against the Bluebirds
Both teams clinched promotion to the Premier League last term as Cardiff were crowned Championship champions and Hull joined them by securing the second automatic spot.
Bruce has targeted this weekend's encounter with Malky Mackay's side as a game both sets of players will believe they can win as they bid to retain their top-flight status come May.
|9/1||Hull City are 9/1 with bet365 to beat Cardiff 2-0
"They will have marked this down as a fixture that they think they can get something from.
"We're against a side that we think is going to be around us in the table and if you can turn those sides over, it's a big feather in your cap and helps enormously.
"It's a big game for us at home. It'll be harder than our last game as well because nobody expected us to do anything against Manchester City.
"The way we played there delighted me because we took part in the game.
"It's important that we play with that same freedom [against Cardiff] and that we express ourselves and go and play. Once you start getting nervous and edgy, it doesn't do anybody any good.
"That was how we tackled the Championship last season and it's what we want to try and do in the Premier League this year. We want to play without the fear and go out there and have a go."