The trip to Anfield will be United's second high-pressure contest this week, following on from Monday's 0-0 draw at home to Chelsea.
Manuel Pelegrini's Manchester City will be desperate to return to winning ways following their surprise 3-2 defeat away to newly-promoted Cardiff City last time out. Malky Mackay's side meanwhile play host to Everton, with new boss Roberto Martinez still seeking his first league win, following draws against Norwich and West Brom.
Chelsea, meanwhile, have a break from domestic duties, as they face Bayern Munich in this season's Uefa Super Cup.
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Last time out, International Football Writer Peter Staunton gave us his predictions, scoring a disapointing 2 out of 10 - but he did manage one perfect score. This week, former Chelsea captain Dennis Wise steps up to the plate!
Dennis has had his say, and now you can too! Leave your predictions in the comments below and vote on how you think he will fare.