The Catalan club announced that Vilanova would be stepping down on Friday in order to continue receiving treatment for throat cancer - the illness that saw him miss large parts of the 2012-13 campaign.
But Laudrup insists he has no knowledge of who Barca may approach, despite being linked with a return to the club where he spent five years of his playing career.
"I can't comment on the speculation, it's all just happened today and even for those in the club who maybe knew about the situation, I still think the announcement will have come as a shock," he told reporters.
"Just a few weeks ago I read he had said he was strong and feeling 100 per cent ahead of the new season, but now he's gone. I don't know what they're going to do so let's see.
"I don't know Vilanova personally but of course I have been following what has happened. It's very sad. I don't know much more than what has been announced tonight. I hope he will get fit again as this is only football and life is more important."
Laudrup led Swansea to ninth in the Premier League last season, as well as securing their first ever major trophy - the Capital One Cup.