Steve Harper captains the Gunners' opposition in his last game for Newcastle, while Olivier Giroud and Jack Wilshere are both on the substitute's bench at St James' Park
The Gunners' north London rivals Tottenham are battling for the last space in the top four of the Premier League and face Sunderland at White Hart Lane knowing that anything but a win will mean a fifth-place finish.
Wojciech Szczesny retains his place in goal ahead of Lukasz Fabianski, while the defence consists of Bacary Sagna, Per Mertesacker, Laurent Koscielny and Kieran Gibbs.
Arteta comes back into the midfield alongisde Aaron Ramsey and Tomas Rosicky, while Theo Walcott and Santi Cazorla partner Lukas Podolski in attack.
Alongisde Fabianski on the bench is Olivier Giroud, who has completed his three-game suspension, and midfielder Jack Wilshere.
For the hosts, Steve Harper will captain the side in his last game for the club, behind a defence of Mathieu Debuchy, Steven Taylor, Fabricio Coloccini and Mapou Yanga-Mbiwa.
Cheikh Tiote starts alongside Yohan Cabaye and Jonas Gutierrez in midfield, while the attack consists of Hatem Ben Arfa, Papiss Cisse and Yoan Gouffran.
Newcastle starting XI: Harper; Debuchy, S.Taylor, Coloccini, Yanga-Mbiwa; Tiote, Cabaye, Gutierrez; Ben Arfa, Cisse, Gouffran.
Subs: Alnwick, Simpson, Anita, Perch, Marveaux, Obertan, Campbell.
Arsenal starting XI: Szczesny; Sagna, Mertesacker, Koscielny, Gibbs; Arteta, Ramsey, Rosicky; Walcott, Podolski, Cazorla.
Subs: Fabianski, Vermaelen, Monreal, Wilshere, Oxlade-Chamberlain, Gervinho, Giroud.