Jamie Carragher and Glen Johnson join the young duo at the back for the Reds at Craven Cottage, while 17-year-old centre-back Lloyd Jones is handed a place among the substitutesAndre Wisdom will start alongside Glen Johnson, Jamie Carragher and Sebastian Coates in defence for Liverpool as they take on Fulham in their penultimate game of the season.
Coates has not started for the Reds since August, while there is also a return for Jonjo Shelvey in midfield. The Englishman's last start came against West Brom in February.
There is also a surprise place on the bench for the highly rated 17-year-old centre-back Lloyd Jones, who could be make his debut for Brendan Rodgers' team if he emerges from among the substitutes.
Meanwhile, Fulham give starts to Aaron Hughes, Kieran Richardson and Alexander Kacaniklic, who were all absent in the Cottagers' 4-2 loss to Reading on May 4.
Fulham are without a win in six games in the league, and are not mathematically clear of relegation. Five points separate themselves and 18th-place Wigan with two games remaining.
Liverpool currently sit five points behind Everton in sixth place following last weekend's 0-0 Merseyside derby draw at Anfield.
Fulham starting XI: Schwarzer; Riether, Hangeland, Hughes, Richardson; Duff, Karagounis, Enoh, Kacaniklic; Ruiz; Berbatov.
Subs: Etheridge, Riise, Senderos, Petric, Frimpong, Rodallega, Emanuelson.
Liverpool starting XI: Reina; Wisdom, Coates, Carragher, Johnson; Lucas, Henderson, Shelvey; Downing, Sturridge, Coutinho.
Subs: Brad Jones, Enrique, Assaidi, Borini, Suso, Coady, Lloyd Jones.