David Luiz drops to defence for the Blues and Demba Ba starts in attack ahead of Fernando Torres, while Eden Hazard's absence allows Victor Moses to continue on the left
Anders Lindegaard starts in goal for Sir Alex Ferguson's side, while Robin van Persie is the lone striker ahead of a five-man midfield flanked by Antonio Valencia and Ryan Giggs.
Anderson, Phil Jones and Tom Cleverley comprise the central midfield trio while Jonny Evans and Nemanja Vidic start at the back ahead of Rio Ferdinand, who is among the substitutes.
Chelsea boss Rafa Benitez, meanwhile, opts to start Demba Ba ahead of Fernando Torres despite the Spaniard's goal in the Europa League semi-final second leg against Basel on Thursday.
Victor Moses keeps his place in the team that saw off the Swiss club in the absence of Eden Hazard, however, while David Luiz drops from midfield to defence and Gary Cahill to the bench.
Ramires and Frank Lampard are paired in central midfield and Oscar and Juan Mata both return to the attack.
Manchester United: Lindegaard; Rafael, Evans, Vidic, Evra; Valencia, Anderson, Jones, Cleverley, Giggs; Van Persie.
Subs: De Gea, Ferdinand, Buttner, Scholes, Kagawa, Chicharito, Rooney.
Chelsea: Cech; Azpilicueta, Ivanovic, David Luiz, Cole; Ramires, Lampard; Oscar, Mata, Moses; Ba.
Subs: Turnbull, Ferreira, Cahill, Terry, Ake, Benayoun, Torres.