Norwich sit six points above the relegation zone with three games to go, and have only managed to win two league games since December after a 10-match unbeaten run was scuppered by Villa in the Capital One Cup.
The Canaries are the league's worst side in the form table, but Hughton doesn't want the players to be thinking about the last time the two sides met.
"It's a massive game for us because of the fact we are playing a team around us, so there is a little more significance in the game," he told reporters.
"As for the game back in December, I don't think it has any bearing on the one coming up.
"You might have seen the away game [a 1-1 draw at Villa in October]. I don't think there is anybody who saw that who didn't think we were the better team on that day, so the cup game is irrelevant.
"Regardless, it's a tough game at this stage of the season whoever it is against."
Carrow Road will welcome back Paul Lambert for the first time on Saturday, the manager who brought Norwich back-to-back promotions from League One to the Premier League.Chris Hughton has branded the game against Aston Villa next Saturday as Norwich enter a "nervy time" with just three games left.