Arsenal supporters are expected to welcome Van Persie back with a hostile reception when newly crowned champions United face the north London outfit.
However, the 29-year-old, elated by his first league title, is braced for those who previously idolised him to vent their feelings following last summer's exit to Old Trafford.
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"Players, staff, managers and even directors come and go, but fans will always stick with their team, so I am looking forward to playing at the Emirates again. I have good memories there and it will be good to see my old colleagues, staff and friends again."
The ex-Gunner spent eight years in north London after moving from Feyenoord in 2004, but could only manage a solitary FA Cup and Community Shield during his stay.
His first-half hat-trick against Aston Villa spared Arsenal from seeing Van Persie seal the Premier League title triumph at his old stomping ground Sunday.
But the Dutchman insists he is just glad to finally win a title after failing to with the Gunners and Feyenoord, and is not even sure whether he will be selected by Sir Alex Ferguson to play against his former team-mates.
He added: "I am so glad we have won the title and it was nice to win it at home in front of our own fans. That was a really great bonus.
"I’m a footballer. I like to play in every game no matter who we play against, but that is up to the boss."